Application Launch Fails with Web Interface using Internet Explorer

Symptoms or Error

After upgrading to Internet Explorer 9 or later, users are unable to launch applications after authentication into Web Interface. Users are given a prompt Do you want to Open, Save, or Cancel the launch.ica connection file.

Note: Clicking Open to run the application is not successful.

If the option to save the file is selected, it is created with a temporary name with a ".partial" extension.

Solution

Complete the following steps to help resolve the issue:

1. Install the latest Citrix Receiver version which can be downloaded from Download Citrix Clients.
2. Add the website URL you are connecting with to the Trusted sites list: 
   1. Click Tools > Internet Options > Security tab.
   2. Add the website to Trusted Sites list to allow the use of the ActiveX ICA client object for the launched connection to be automatically accepted.
       

If you are still experiencing issues try the following steps:
1. Run the following tool to clean-up a corrupt or previous installation of Citrix Receiver: CTX137494 - Receiver Clean-Up Utility
2. Verify in your Windows Control Panel in Programs and Features or Add/Remove Programs that the Citrix Receiver software is no longer present.
3. Reboot your computer.
4. Download and install the latest Citrix Receiver
Note: A fix was first introduced with the original release 12.1.44 version of the Citrix Online Plug-in. CTX126653 – Citrix Online Plug-in for Windows with Internet Explorer 9 Support

If using older legacy Citrix clients, this issue was addressed with the latest available Citrix Online Plug-in.

Workaround

Caution! Refer to the Disclaimer at the end of this article before using Registry Editor. 

Configure Internet Explorer as follows to allow successful application launching:

1. Disable ActiveX filtering feature for the Web Interface site, either by:

• Disabling ActiveX filtering globally:
  Click Gear icon, select Safety, de-select ActiveX Filtering. Alternatively, press Alt key and click Tools menu (ActiveX filtering is enabled if a “tick” appears next to it and is disabled if the “tick” disappears).
  
  
  Or
• Disabling ActiveX filtering for an individual site when ActiveX filtering is enabled globally:
  1. Log on to the Web Interface site and attempt to launch an application. At the end of the address bar a blue warning sign appears, indicating filtered content.
     
  2. Click the blue warning sign and select Turn off ActiveX Filtering.

2. Enable ICA launch using one of the following options:

• Add the site to the Trusted sites list: In the Security tab of Internet Options, add the Web Interface site to Trusted Sites list to allow the use of the ActiveX ICA client object for the launch.
  Or

• Disable the MIME filter: Rename the following registry key: HKEY_CLASSES_ROOT\PROTOCOLS\Filter\application/x-ica

3. Log off Web Interface, close and then restart the browser after making this change.

http://support.citrix.com/article/CTX129082